Those whose bodies resist aspirin may show a higher risk if serious strokes, as indicated by a study which will be presented at the up and coming yearly meeting of the American Academy of Neurology in April.
For the study, a group of researchers reviewed over 310 patients who had been under a seven day treatment with aspirin prior to an ischemic stroke. After the patients were admitted for having a stroke, the specialist screened them for aspirin resistance within the same day.
The medics uncovered that 27.7% of the study subjects had an immune system that rejected the aspirin. Their strokes went from three to eleven on a stroke severity scale, contrasted with ranks of one to six among those whose body accepted the aspirin treatment.
What is more, strokes of patients rejecting aspirin had a more serious effect on the brain area than the strokes of aspirin responders. More exactly, the strike was received twice as hard by the brain.
Lead analyst Mi Sun Oh, MD, of the branch of neurology at the Hallym University College of Medicine in Seoul, South Korea was quoted by HealthDay making the following remarks:
“Aspirin resistance is an important predictor of severe stroke and large stroke size in patients taking aspirin before having a stroke. In patients at high risk for stroke with aspirin resistance, different anti-clotting drugs — such as clopidogrel (Plavix) — can be considered as alternatives to prevent another stroke or decrease stroke severity.”
Comparative connections between aspirin immunity and stroke level have been also observed in a small research from Australia. However, in that case the value of point-of-care diagnostic screening and the presence of aspirin resistance have been challenged by other studies.
Aspirin resistance in the recent study was estimated by no less than 550 aspirin reaction units (ARU)) on the VerifyNow measure and it results connected it with an altogether higher starting NIH Stroke Scale (NIHSS) score.
The average NIHSS score was 4 in that aspirin resistant group of patients compared to 3 in other aspirin responding stroke patients, which remained altogether diverse in a multivariate balanced model even if both were included into the minor stroke class.
Aspirin resistance was additionally linked to increased infarct volume on diffusion-weighted MRI: 2.8 cc versus 1.6 cc among aspirin responders.
According to Oh, in the long run doctors may have the instruments to detect individuals who are prone to reject aspirin treatment and provide for them bigger doses or other medications to avert blood cloths. But Oh also cautioned that researchers need better approaches to detect individuals with aspirin resistance before any progressions can be made. The analyst recommended people who are using low-dose aspirin to avert blood coagulating and stroke to keep taking their treatments.
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